Genetic factors regarding panic disorder |
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Posted Date: 6/30/2009 |
Blog by: poost |
Viewed: 104
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Category: Mental Health Disorders » Anxiety - Panic Disorders |
Panic disorder is a very common ailment among all the psychiatric illnesses. It is a condition in which the individual fails to control the worry. At times this worry overwhelms him and causes him to panic.
The etiology of panic disorder is not clear like many other neurological diseases. The various factors considered to be responsible include environmental factors and genetics. The role of genetics is not completely understood but is still of great importance regarding this disorder. It is also considered to be related on genetic and biological basis with other neurological diseases like major depression, generalized anxiety disorder and obsessive compulsive disorder. All of these diseases are considered to run in families and are thought to be inheritable.
Various studies and researches regarding this disease have shown that it has a definite tendency to run in families. No exact gene has been identified carrying the trait but it is evident from research that the first degree relatives of a person suffering from panic disorder tend to have a greater risk of adopting this illness and also have an increased risk of suffering from major depression. So along with have some genetic basis which makes it a familial disease it shares some common traits with major depression.
Along with the study of familial predisposition to this disease different twin studies have also been carried out to test the hypothesis that whether this disease is distributed genetically or not. The studies show that the genetically identical twins have much greater risk of suffering from this disorder if one of them has also developed this ailment. The risk is much less in fraternal twins as they do have less common genetics but still they are quite high risk individuals. After them the first degree relatives are considered to be high risk as compared to the general population.
Different studies have been carried out regarding the effect of caffeine upon individuals which is known to produce anxiety. It acts through the Adenosine receptors and studies have shown that the individuals suffering from panic disorder are more prone to the anxiety producing effect of caffeine. In another study it has been proven through systemic mutation screening and association studies between A1 and A2a receptors that there exists a definitive relationship between 1976T allele and 1976T/T genotype regarding the adenosine receptors and panic disorder. The 1976T/T genotype is associated with both the increased response to caffeine induced anxiety as well as the panic disorder.
Various other researchers have been carried out throughout the world regarding genetic factors associated with panic disorder. The Finish scientists have according to them identified the gene responsible for anxiety. This research was carried out under the supervision of Academy of Research Fellow liris Howatta. This study had its primary focus on the different genes responsible for human behavior some of the studied genes showed a relationship which was statistical with panic disorder and other specific forms of anxiety as well. This research was carried out as a part of the Academy of Finland research program on neuroscience. The most interesting fact was that different genes showed different associations with different types of anxiety disorders like panic disorders, manias, social phobias and generalized anxiety disorder. Different counterparts of this research are being carried out internationally as well to see whether the targeted genes have same ratio in other races around the globe as well.
The establishment of the exact genes responsible for panic disorder will be of great help to device a better treatment strategy for this disease which is a serious deficiency in this modern era.
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